Protein name:
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1 ;
Alternative:
Phosphoinositide phospholipase C-gamma-1 ;PLC-148 ;Phospholipase C-gamma-1 (PLC-gamma-1) ;Phospholipase C-II (PLC-II) ;
Organism:
Bovine (Bos taurus).
General Annotation
Sub Unit:
Interacts (via SH2 domain) with FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts (via SH3 domain) with AGAP2. Interacts with LAT (phosphorylated) upon TCR activation. Interacts (via SH3 domain) with the Pro-rich domain of TNK1. Associates with BLNK, VAV1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB in activated T-cells; which inhibits phosphorylation. Interacts with SHB. Interacts (via SH3 domain) with the Arg/Gly-rich-flanked Pro-rich domains of KHDRBS1/SAM68. This interaction is selectively regulated by arginine methylation of KHDRBS1/SAM68. Interacts with INPP5D/SHIP1, THEMIS and CLNK (By similarity). Interacts with RALGPS1 (By similarity). Interacts (via SH3 domain) with HEV ORF3 protein. Interacts (via the SH2 domains) with VIL1 (phosphorylated at C-terminus tyrosine phosphorylation sites). Interacts with AXL and KIT (By similarity). Interacts (via SH2 domain) with RET.
Function:
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as fibroblast growth factor receptors. Plays a role in actin reorganization and cell migration.
Subcellular Location:
Cell projection
lamellipodium
Cell projection
ruffle
Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment.
Protein Attributes:
50:
MAGAASPCAN | GCGPSAPSDA | EVVHLCRSLE | VGTVMTLFYS | KKSQRPERKT |
100:
FQVKLETRQI | TWSRGADKIE | GAIDIREIKE | IRPGKTSRDF | DRYQEDPAFR |
150:
PDQSHCFVIL | YGMEFRLKTL | SLQATSEDEV | NMWIRGLTWL | MEDTLQAATP |
200:
LQIERWLRKQ | FYSVDRNRED | RISAKDLKNM | LSQVNYRVPN | MRFLRERLTD |
250:
LEQRTSDITY | GQFAQLYRSL | MYSAQKTMDL | PFLEASALRA | GERPELCRVS |
300:
LPEFQQFLLE | YQGELWAVDR | LQVQEFMLSF | LRDPLREIEE | PYFFLDEFVT |
350:
FLFSKENSIW | NSQLDEVCPD | TMNNPLSHYW | ISSSHNTYLT | GDQFSSESSL |
400:
EAYARCLRMG | CRCIELDCWD | GPDGMPVIYH | GHTLTTKIKF | SDVLHTIKEH |
450:
AFVASEYPVI | LSIEDHCSIA | QQRNMAQYFK | KVLGDTLLTK | PVDIAADGLP |
500:
SPNQLKRKIL | IKHKKLAEGS | AYEEVPTSVM | YSENDISNSI | KNGILYLEDP |
550:
VNHEWYPHYF | VLTSSKIYYS | EETSSDQGNE | DEEEPKEASG | STELHSNEKW |
600:
FHGKLGAGRD | GRHIAERLLT | EYCIETGAPD | GSFLVRESET | FVGDYTLSFW |
650:
RNGKVQHCRI | HSRQDAGTPK | FFLTDNLVFD | SLYDLITHYQ | QVPLRCNEFE |
700:
MRLSEPVPQT | NAHESKEWYH | ASLTRAQAEH | MLMRVPRDGA | FLVRKRNEPN |
750:
SYAISFRAEG | KIKHCRVQQE | GQTVMLGNSE | FDSLVDLISY | YEKHPLYRKM |
800:
KLRYPINEEA | LEKIGTAEPD | YGALYEGRNP | GFYVEANPMP | TFKCAVKALF |
850:
DYKAQREDEL | TFTKSAIIQN | VEKQEGGWWR | GDYGGKKQLW | FPSNYVEEMV |
900:
SPAALEPERE | HLDENSPLGD | LLRGVLDVPA | CQIAVRPEGK | NNRLFVFSIS |
950:
MASVAHWSLD | VAADSQEELQ | DWVKKIREVA | QTADARLTEG | KMMERRKKIA |
1000:
LELSELVVYC | RPVPFDEEKI | GTERACYRDM | SSFPETKAEK | YVNKAKGKKF |
1050:
LQYNRLQLSR | IYPKGQRLDS | SNYDPLPMWI | CGSQLVALNF | QTPDKPMQMN |
1100:
QALFLAGGHC | GYVLQPSVMR | DEAFDPFDKS | SLRGLEPCAI | CIEVLGARHL |
1150:
PKNGRGIVCP | FVEIEVAGAE | YDSIKQKTEF | VVDNGLNPVW | PAKPFHFQIS |
1200:
NPEFAFLRFV | VYEEDMFSDQ | NFLAQATFPV | KGLKTGYRAV | PLKNNYSEGL |
1250:
ELASLLVKID | VFPAKQENGD | LSPFGGASLR | ERSCDASGPL | FHGRAREGSF |
1291:
EARYQQPFED | FRISQEHLAD | HFDGRDRRTP | RRTRVNGDNR | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
ELISA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
CLIA Kit for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Polyclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Monoclonal Antibody for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
Protein for Bovine 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-771; TYR-783 AND TYR-1254
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-771; TYR-783 AND TYR-1254
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PDGFRA
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-783 AND TYR-1254
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RET
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 663-759